Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Glecaprevir / pibrentasvir
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit OATP1B1/1B3 and may raise olmesartan concentrations. The effect is generally modest and may lead to hypotension or renal effects.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake of olmesartan.
What to do
Monitor blood pressure during the hepatitis C treatment course and adjust the olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit OATP1B1/1B3 and may raise olmesartan concentrations. The effect is generally modest and may lead to hypotension or renal effects.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during the hepatitis C treatment course and adjust the olmesartan dose if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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