Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Glibenclamide
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and so may weaken the glucose-lowering effect of glyburide. The effect is usually small at low thiazide doses but can unmask poor glycemic control.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Glibenclamide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion plus insulin resistance oppose sulfonylurea action.
What to do
Monitor blood glucose and HbA1c after starting or changing the combination, and adjust the antidiabetic regimen if control worsens; keep potassium in the normal range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Glibenclamide?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and so may weaken the glucose-lowering effect of glyburide. The effect is usually small at low thiazide doses but can unmask poor glycemic control.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the combination, and adjust the antidiabetic regimen if control worsens; keep potassium in the normal range.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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