Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Grapefruit
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit inhibits intestinal CYP3A4 and may modestly increase amlodipine exposure. The increase is generally small and rarely clinically significant.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 reduces first-pass metabolism of amlodipine.
What to do
Routine avoidance is not required; monitor for hypotension or edema with large daily intake.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Grapefruit?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit inhibits intestinal CYP3A4 and may modestly increase amlodipine exposure. The increase is generally small and rarely clinically significant.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Routine avoidance is not required; monitor for hypotension or edema with large daily intake.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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