Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Griseofulvin
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a CYP3A4 inducer and may lower amlodipine concentrations. This could reduce blood pressure control during prolonged treatment.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Griseofulvin belongs to Anti Fungals.
Why it happens
Induction of CYP3A4 by griseofulvin increases the metabolism of amlodipine.
What to do
Monitor blood pressure during and after griseofulvin therapy. Increase the amlodipine dose if control is lost, and reassess when griseofulvin is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Griseofulvin
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Griseofulvin?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a CYP3A4 inducer and may lower amlodipine concentrations. This could reduce blood pressure control during prolonged treatment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and after griseofulvin therapy. Increase the amlodipine dose if control is lost, and reassess when griseofulvin is stopped.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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