Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Hydrocortisone
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone with hydrochlorothiazide increases potassium loss and the risk of hypokalemia, and its mineralocorticoid activity may also cause fluid retention that blunts the antihypertensive effect. Hydrocortisone may slightly lower amlodipine exposure through CYP3A4 induction, which is of limited importance.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting and sodium retention opposing antihypertensive effect, with weak CYP3A4 induction.
What to do
Monitor serum potassium and blood pressure, particularly with systemic or prolonged hydrocortisone use, and supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Hydrocortisone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone with hydrochlorothiazide increases potassium loss and the risk of hypokalemia, and its mineralocorticoid activity may also cause fluid retention that blunts the antihypertensive effect. Hydrocortisone may slightly lower amlodipine exposure through CYP3A4 induction, which is of limited importance.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, particularly with systemic or prolonged hydrocortisone use, and supplement potassium if needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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