Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Indacaterol inhaled
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta2-agonists can lower serum potassium, and hydrochlorothiazide causes renal potassium loss. The combination may increase hypokalemia, though inhaled indacaterol has limited systemic effect at usual doses.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta2-mediated potassium shift and thiazide renal potassium loss.
What to do
Monitor serum potassium, especially in patients with COPD exacerbation or hypoxia, and correct deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta2-agonists can lower serum potassium, and hydrochlorothiazide causes renal potassium loss. The combination may increase hypokalemia, though inhaled indacaterol has limited systemic effect at usual doses.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially in patients with COPD exacerbation or hypoxia, and correct deficits.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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