Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Insulin degludec / insulin aspart
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan may enhance insulin sensitivity and lower glucose, whereas hydrochlorothiazide can cause hyperglycemia. The net effect varies and can destabilize glycemic control.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing effects: ARB-related improved insulin sensitivity versus thiazide-induced impaired glucose tolerance, partly via hypokalemia.
What to do
Monitor blood glucose and potassium when starting or changing therapy, and adjust insulin doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan may enhance insulin sensitivity and lower glucose, whereas hydrochlorothiazide can cause hyperglycemia. The net effect varies and can destabilize glycemic control.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when starting or changing therapy, and adjust insulin doses accordingly.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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