Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Isradipine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two dihydropyridine calcium channel blockers duplicates therapy and adds little antihypertensive benefit. It increases the risk of hypotension, flushing, headache, reflex tachycardia and peripheral edema.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive L-type calcium channel blockade and vasodilation from two drugs of the same class.
What to do
Avoid concurrent use and keep only one dihydropyridine. If overlap is unavoidable, monitor blood pressure and heart rate closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Isradipine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two dihydropyridine calcium channel blockers duplicates therapy and adds little antihypertensive benefit. It increases the risk of hypotension, flushing, headache, reflex tachycardia and peripheral edema.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep only one dihydropyridine. If overlap is unavoidable, monitor blood pressure and heart rate closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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