Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Magnesium chloride
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Magnesium chloride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium excretion and can lead to hypomagnesemia over time, offsetting magnesium supplementation. This may be relevant in patients with arrhythmia risk or on long-term therapy.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced increase in renal magnesium excretion.
What to do
Monitor serum magnesium during long-term thiazide therapy and adjust magnesium supplementation as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Magnesium chloride?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide increases urinary magnesium excretion and can lead to hypomagnesemia over time, offsetting magnesium supplementation. This may be relevant in patients with arrhythmia risk or on long-term therapy.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Magnesium chloride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium during long-term thiazide therapy and adjust magnesium supplementation as needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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