Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Magnesium sulfate
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide promotes urinary magnesium wasting and may lower serum magnesium, partly counteracting magnesium replacement. Parenteral magnesium sulfate also has its own additive vasodilating effect with amlodipine, but the main concern is altered magnesium balance.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide diuretics increase renal magnesium excretion, which reduces retained magnesium.
What to do
Check serum magnesium and renal function when giving magnesium sulfate to patients on thiazides, and adjust the dose according to levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Magnesium sulfate?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide promotes urinary magnesium wasting and may lower serum magnesium, partly counteracting magnesium replacement. Parenteral magnesium sulfate also has its own additive vasodilating effect with amlodipine, but the main concern is altered magnesium balance.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum magnesium and renal function when giving magnesium sulfate to patients on thiazides, and adjust the dose according to levels.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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