Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Methyclothiazide
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains a thiazide diuretic, so adding methyclothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hypotension, although the ARB partly offsets potassium loss.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate thiazide diuretic activity with additive electrolyte and volume effects.
What to do
Avoid combining two thiazides and stop the duplicate. Monitor electrolytes, renal function and blood pressure if overlap occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Methyclothiazide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains a thiazide diuretic, so adding methyclothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hypotension, although the ARB partly offsets potassium loss.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides and stop the duplicate. Monitor electrolytes, renal function and blood pressure if overlap occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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