Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Metipranolol
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Metipranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metipranolol eye drops are a nonselective beta-blocker that can be absorbed systemically and add to the blood pressure and heart rate lowering of antihypertensives. Combined with amlodipine, hypotension, bradycardia or conduction problems are possible, especially in older patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Metipranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effects of systemic beta-blockade and calcium channel blockade or other antihypertensives.
What to do
Monitor blood pressure and heart rate when starting metipranolol drops, and teach patients punctal occlusion to limit systemic absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Metipranolol?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Metipranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metipranolol eye drops are a nonselective beta-blocker that can be absorbed systemically and add to the blood pressure and heart rate lowering of antihypertensives. Combined with amlodipine, hypotension, bradycardia or conduction problems are possible, especially in older patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Metipranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting metipranolol drops, and teach patients punctal occlusion to limit systemic absorption.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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