Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Mycophenolate
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and mycophenolic acid glucuronide may compete for renal tubular secretion. This could modestly raise levels of the glucuronide metabolite, but the clinical effect is uncertain.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion of anionic compounds.
What to do
No routine change needed. Watch for mycophenolate adverse effects such as cytopenias and GI intolerance, especially with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Mycophenolate?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide and mycophenolic acid glucuronide may compete for renal tubular secretion. This could modestly raise levels of the glucuronide metabolite, but the clinical effect is uncertain.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed. Watch for mycophenolate adverse effects such as cytopenias and GI intolerance, especially with reduced renal function.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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