Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Nitroglycerin rectal
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a venodilator that lowers blood pressure. Together with a combination of three antihypertensives, hypotension and dizziness may be more pronounced, especially in volume-depleted patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure reduction.
What to do
Monitor blood pressure and advise slow changes in posture. Adjust doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a venodilator that lowers blood pressure. Together with a combination of three antihypertensives, hypotension and dizziness may be more pronounced, especially in volume-depleted patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and advise slow changes in posture. Adjust doses if symptomatic hypotension develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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