Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Olmesartan
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Olmesartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains olmesartan, so adding separate olmesartan duplicates the dose of the same drug, increasing the risk of hypotension, hyperkalemia and renal impairment.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Duplicated angiotensin II type 1 receptor blockade from the same substance produces exaggerated hypotensive and renal effects.
What to do
Avoid concurrent use of separate olmesartan with the combination product and review the prescription for duplication. If an overdose is possible, monitor blood pressure, potassium and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Olmesartan?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination product already contains olmesartan, so adding separate olmesartan duplicates the dose of the same drug, increasing the risk of hypotension, hyperkalemia and renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Olmesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of separate olmesartan with the combination product and review the prescription for duplication. If an overdose is possible, monitor blood pressure, potassium and creatinine.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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