Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Ombitasvir / paritaprevir / ritonavir and dasabuvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted paritaprevir regimens strongly inhibit CYP3A4 and markedly increase amlodipine exposure. This can lead to hypotension and edema.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ritonavir and paritaprevir inhibit CYP3A4, reducing amlodipine clearance.
What to do
Reduce the amlodipine dose by at least half and monitor for hypotension and edema; consider an alternative antihypertensive if effects persist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted paritaprevir regimens strongly inhibit CYP3A4 and markedly increase amlodipine exposure. This can lead to hypotension and edema.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the amlodipine dose by at least half and monitor for hypotension and edema; consider an alternative antihypertensive if effects persist.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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