Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Quinupristin / dalfopristin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Quinupristin / dalfopristin: moderate interaction.
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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase amlodipine exposure, causing hypotension or edema. Clinical significance is usually limited because therapy is short.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of amlodipine.
What to do
Monitor blood pressure during the antibiotic course and reduce the amlodipine dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may increase amlodipine exposure, causing hypotension or edema. Clinical significance is usually limited because therapy is short.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during the antibiotic course and reduce the amlodipine dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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