Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Rifampin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces CYP3A4 and can substantially lower amlodipine concentrations. Blood pressure control may be lost during rifampin therapy and can rebound after it is stopped.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic and intestinal CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure and titrate amlodipine upward if needed, or switch to an agent less affected by induction. Reassess the dose after rifampin is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Rifampin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin strongly induces CYP3A4 and can substantially lower amlodipine concentrations. Blood pressure control may be lost during rifampin therapy and can rebound after it is stopped.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate amlodipine upward if needed, or switch to an agent less affected by induction. Reassess the dose after rifampin is discontinued.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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