Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Sacubitril / valsartan
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan and valsartan both block the angiotensin II type 1 receptor, so combining them gives dual receptor blockade without a clear added benefit. The result can be more hypotension, hyperkalemia and renal impairment. The hydrochlorothiazide component may partly offset the potassium rise but does not remove the risk.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate angiotensin receptor blockade with additive effects on hypotension, aldosterone suppression, potassium retention and renal hemodynamics.
What to do
Avoid using the two together and stop the olmesartan-containing product when sacubitril/valsartan is started. If overlap is unavoidable, monitor blood pressure, serum potassium and creatinine closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Sacubitril / valsartan?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olmesartan and valsartan both block the angiotensin II type 1 receptor, so combining them gives dual receptor blockade without a clear added benefit. The result can be more hypotension, hyperkalemia and renal impairment. The hydrochlorothiazide component may partly offset the potassium rise but does not remove the risk.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together and stop the olmesartan-containing product when sacubitril/valsartan is started. If overlap is unavoidable, monitor blood pressure, serum potassium and creatinine closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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