Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Salicylates
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have NSAID-like effects on renal prostaglandins and can blunt the antihypertensive effect of olmesartan and hydrochlorothiazide. In volume-depleted or elderly patients, the combination can also worsen renal function. Potassium effects are variable.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal vasodilatory prostaglandins reduces natriuresis and renal perfusion, opposing the diuretic and angiotensin receptor blocker effects.
What to do
Monitor blood pressure, renal function and serum potassium, especially in elderly or dehydrated patients. Keep the salicylate dose low and the duration short, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Salicylates?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have NSAID-like effects on renal prostaglandins and can blunt the antihypertensive effect of olmesartan and hydrochlorothiazide. In volume-depleted or elderly patients, the combination can also worsen renal function. Potassium effects are variable.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and serum potassium, especially in elderly or dehydrated patients. Keep the salicylate dose low and the duration short, and ensure adequate hydration.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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