Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Salsalate
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a non-acetylated salicylate, can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. Together with an ARB and diuretic it may impair renal function, particularly in elderly or volume-depleted patients. It may also affect potassium balance.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and lowers glomerular perfusion, which opposes the antihypertensives and adds to renal risk.
What to do
Monitor blood pressure, serum creatinine and potassium, particularly in the first weeks and in at-risk patients. Maintain hydration and use the lowest effective salsalate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Salsalate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a non-acetylated salicylate, can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. Together with an ARB and diuretic it may impair renal function, particularly in elderly or volume-depleted patients. It may also affect potassium balance.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, particularly in the first weeks and in at-risk patients. Maintain hydration and use the lowest effective salsalate dose.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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