Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations cause fluid and electrolyte shifts, and combining them with a diuretic and ARB increases the risk of dehydration, renal injury and arrhythmia. Amlodipine adds some hypotensive effect.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance, with impaired renal perfusion from diuretic and ARB action.
What to do
Consider withholding the diuretic and olmesartan combination on the day of bowel preparation and ensure adequate fluid intake. Monitor electrolytes and creatinine in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations cause fluid and electrolyte shifts, and combining them with a diuretic and ARB increases the risk of dehydration, renal injury and arrhythmia. Amlodipine adds some hypotensive effect.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding the diuretic and olmesartan combination on the day of bowel preparation and ensure adequate fluid intake. Monitor electrolytes and creatinine in high-risk patients.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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