Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Sulfamethoxazole
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole (usually with trimethoprim) and hydrochlorothiazide can both lower serum sodium, and the trimethoprim component raises potassium, which is also relevant with olmesartan. Combined use may cause hyponatremia or hyperkalemia, especially in older or renally impaired patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on sodium loss, plus trimethoprim ENaC blockade and angiotensin receptor blockade reducing potassium excretion.
What to do
Monitor serum sodium, potassium and creatinine within the first week of co-therapy, particularly in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole (usually with trimethoprim) and hydrochlorothiazide can both lower serum sodium, and the trimethoprim component raises potassium, which is also relevant with olmesartan. Combined use may cause hyponatremia or hyperkalemia, especially in older or renally impaired patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium and creatinine within the first week of co-therapy, particularly in elderly patients.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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