Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Synthetic human angiotensin ii
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan blocks the angiotensin II type 1 receptor and so can reduce the pressor response to administered angiotensin II. Higher angiotensin II doses may be needed in vasodilatory shock for patients on ARBs.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at the AT1 receptor.
What to do
Titrate angiotensin II to blood pressure response, expecting a possibly higher dose requirement, and monitor hemodynamics continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan blocks the angiotensin II type 1 receptor and so can reduce the pressor response to administered angiotensin II. Higher angiotensin II doses may be needed in vasodilatory shock for patients on ARBs.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to blood pressure response, expecting a possibly higher dose requirement, and monitor hemodynamics continuously.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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