Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Terbutaline
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline and hydrochlorothiazide can both lower serum potassium, with an additive effect that may provoke arrhythmias, especially with high-dose or parenteral beta-agonist use. Terbutaline may also cause tachycardia that offsets antihypertensive effect.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Beta-2 stimulation shifts potassium into cells while thiazide diuresis increases renal potassium loss.
What to do
Monitor serum potassium and heart rhythm in patients on frequent or high-dose terbutaline, and replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Terbutaline?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline and hydrochlorothiazide can both lower serum potassium, with an additive effect that may provoke arrhythmias, especially with high-dose or parenteral beta-agonist use. Terbutaline may also cause tachycardia that offsets antihypertensive effect.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and heart rhythm in patients on frequent or high-dose terbutaline, and replace potassium if low.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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