Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Trilostane
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Trilostane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilostane inhibits adrenal steroid synthesis, including aldosterone, which can reduce potassium excretion. With olmesartan this may raise the risk of hyperkalemia, while hydrochlorothiazide counters it partly.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 3-beta-hydroxysteroid dehydrogenase lowers aldosterone, causing additive potassium retention with angiotensin receptor blockade.
What to do
Monitor serum potassium and blood pressure when combining, and avoid potassium supplements unless hypokalemia is documented.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Trilostane?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilostane inhibits adrenal steroid synthesis, including aldosterone, which can reduce potassium excretion. With olmesartan this may raise the risk of hyperkalemia, while hydrochlorothiazide counters it partly.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Trilostane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure when combining, and avoid potassium supplements unless hypokalemia is documented.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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