Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Trimagnesium
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Trimagnesium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium has calcium-antagonist properties and may add to the vasodilation of amlodipine. This can cause hypotension or muscle weakness, mostly with high magnesium doses. Thiazides, in contrast, tend to lower magnesium.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Trimagnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive calcium channel antagonism and vasodilation from magnesium and amlodipine.
What to do
Monitor blood pressure if large doses of magnesium are used, and watch for muscle weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Trimagnesium?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Trimagnesium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium has calcium-antagonist properties and may add to the vasodilation of amlodipine. This can cause hypotension or muscle weakness, mostly with high magnesium doses. Thiazides, in contrast, tend to lower magnesium.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Trimagnesium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if large doses of magnesium are used, and watch for muscle weakness.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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