Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can lower serum potassium and prolong QTc, effects that add to the potassium loss caused by hydrochlorothiazide. The risk is greatest if the beta-agonist dose is exceeded or in patients with other risk factors for arrhythmia.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-2 agonism shifts potassium into cells, while thiazide diuresis increases renal potassium loss, producing additive hypokalemia.
What to do
Check serum potassium and magnesium periodically, particularly in patients with cardiac disease or other hypokalemia risks. Replace potassium if levels are low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilanterol, a long-acting beta-agonist, can lower serum potassium and prolong QTc, effects that add to the potassium loss caused by hydrochlorothiazide. The risk is greatest if the beta-agonist dose is exceeded or in patients with other risk factors for arrhythmia.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium periodically, particularly in patients with cardiac disease or other hypokalemia risks. Replace potassium if levels are low.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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