Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Vilanterol / fluticasone furoate inhaled
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol can reduce serum potassium and cause ECG changes, which may be compounded by the potassium-wasting effect of hydrochlorothiazide. Clinically significant effects are most likely at high doses or in susceptible patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypokalemia from beta-2 mediated intracellular potassium shift and thiazide-induced renal potassium loss.
What to do
Monitor serum potassium in patients with additional risk factors such as heart disease or high doses. Correct hypokalemia and hypomagnesemia if present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilanterol can reduce serum potassium and cause ECG changes, which may be compounded by the potassium-wasting effect of hydrochlorothiazide. Clinically significant effects are most likely at high doses or in susceptible patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with additional risk factors such as heart disease or high doses. Correct hypokalemia and hypomagnesemia if present.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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