Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Xipamide
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Xipamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, so adding it to hydrochlorothiazide duplicates the diuretic class. This increases the risk of hypotension, volume depletion, hypokalemia, hyponatremia and renal impairment, and also adds to the effect of olmesartan and amlodipine.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Xipamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate inhibition of distal tubular sodium reabsorption, with additive hypotensive effects.
What to do
Avoid combining two thiazide-type diuretics unless clearly intended. If used together, monitor electrolytes, renal function and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Xipamide?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Xipamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Xipamide is a thiazide-like diuretic, so adding it to hydrochlorothiazide duplicates the diuretic class. This increases the risk of hypotension, volume depletion, hypokalemia, hyponatremia and renal impairment, and also adds to the effect of olmesartan and amlodipine.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Xipamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide-type diuretics unless clearly intended. If used together, monitor electrolytes, renal function and blood pressure closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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