Drug interactions
Amlodipine-valsartan + Chlorothiazide
Severity: Minor
Amlodipine-valsartan and Chlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide adds to the blood pressure lowering of the combination and may cause volume depletion and hypotension. Its potassium loss partially offsets valsartan's potassium retention, so the net effect on potassium varies.
What this interaction means in plain words
Amlodipine-valsartan and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with opposing effects on potassium handling between the thiazide and ARB.
What to do
Monitor blood pressure, potassium, sodium and renal function after starting or changing doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Amlodipine-valsartan with Chlorothiazide?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorothiazide adds to the blood pressure lowering of the combination and may cause volume depletion and hypotension. Its potassium loss partially offsets valsartan's potassium retention, so the net effect on potassium varies.
How serious is the interaction between Amlodipine-valsartan and Chlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium, sodium and renal function after starting or changing doses.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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