Drug interactions
Amlodipine-valsartan + Felodipine
Severity: Moderate
Amlodipine-valsartan and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and felodipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds little benefit and increases hypotension, peripheral edema, flushing and dizziness.
What this interaction means in plain words
Amlodipine-valsartan and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Felodipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic L-type calcium channel blockade in vascular smooth muscle.
What to do
Avoid using two dihydropyridine calcium channel blockers together; choose one and adjust its dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Amlodipine-valsartan with Felodipine?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and felodipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds little benefit and increases hypotension, peripheral edema, flushing and dizziness.
How serious is the interaction between Amlodipine-valsartan and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two dihydropyridine calcium channel blockers together; choose one and adjust its dose.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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