Drug interactions
Amlodipine-valsartan + Isavuconazonium
Severity: Moderate
Amlodipine-valsartan and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise amlodipine concentrations. This may increase hypotension and peripheral edema. The effect of amlodipine on isavuconazole exposure is expected to be small.
What this interaction means in plain words
Amlodipine-valsartan and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4-mediated metabolism of amlodipine.
What to do
Monitor blood pressure and edema when the azole is started or stopped. Reduce the amlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Isavuconazonium?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active moiety of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise amlodipine concentrations. This may increase hypotension and peripheral edema. The effect of amlodipine on isavuconazole exposure is expected to be small.
How serious is the interaction between Amlodipine-valsartan and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when the azole is started or stopped. Reduce the amlodipine dose if hypotension or edema develops.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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