Drug interactions
Amlodipine-valsartan + Lesinurad
Severity: Minor
Amlodipine-valsartan and Lesinurad: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is a weak CYP3A inducer and could slightly lower amlodipine concentrations. The clinical effect is expected to be small, though blood pressure control could be modestly reduced.
What this interaction means in plain words
Amlodipine-valsartan and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Lesinurad belongs to Genitourinary.
Why it happens
Weak induction of CYP3A4 by lesinurad may increase amlodipine metabolism.
What to do
No routine dose change is needed; check blood pressure if control appears to worsen after lesinurad is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Frequently asked questions
Can I take Amlodipine-valsartan with Lesinurad?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lesinurad is a weak CYP3A inducer and could slightly lower amlodipine concentrations. The clinical effect is expected to be small, though blood pressure control could be modestly reduced.
How serious is the interaction between Amlodipine-valsartan and Lesinurad?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; check blood pressure if control appears to worsen after lesinurad is started.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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