Drug interactions
Amlodipine-valsartan + Metyrapone
Severity: Minor
Amlodipine-valsartan and Metyrapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No clinically established interaction exists between metyrapone and valsartan or amlodipine. Metyrapone may induce CYP3A4 and therefore could modestly reduce amlodipine exposure, but this is not well documented.
What this interaction means in plain words
Amlodipine-valsartan and Metyrapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Metyrapone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction by metyrapone; no established mechanism for valsartan.
What to do
Monitor blood pressure after starting metyrapone and adjust antihypertensives if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Budesonide + Metyrapone Moderate
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Deflazacort + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
Frequently asked questions
Can I take Amlodipine-valsartan with Metyrapone?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Metyrapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No clinically established interaction exists between metyrapone and valsartan or amlodipine. Metyrapone may induce CYP3A4 and therefore could modestly reduce amlodipine exposure, but this is not well documented.
How serious is the interaction between Amlodipine-valsartan and Metyrapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting metyrapone and adjust antihypertensives if control changes.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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