Drug interactions
Amlodipine-valsartan + Nicardipine
Severity: Moderate
Amlodipine-valsartan and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a second dihydropyridine calcium channel blocker, so adding it to amlodipine duplicates the same therapeutic class. This can cause excessive vasodilation with hypotension, dizziness, flushing, peripheral edema and reflex tachycardia, with no added benefit.
What this interaction means in plain words
Amlodipine-valsartan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Additive L-type calcium channel blockade and vasodilation from two dihydropyridines.
What to do
Avoid combining two dihydropyridine calcium channel blockers; choose a single agent and titrate it. If both are briefly co-administered, monitor blood pressure, heart rate and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-valsartan and Nicardipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Amlodipine-valsartan with Nicardipine?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a second dihydropyridine calcium channel blocker, so adding it to amlodipine duplicates the same therapeutic class. This can cause excessive vasodilation with hypotension, dizziness, flushing, peripheral edema and reflex tachycardia, with no added benefit.
How serious is the interaction between Amlodipine-valsartan and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridine calcium channel blockers; choose a single agent and titrate it. If both are briefly co-administered, monitor blood pressure, heart rate and edema.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
