Drug interactions
Amlodipine-valsartan + Ritonavir
Severity: Moderate
Amlodipine-valsartan and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and raises amlodipine levels, increasing the risk of hypotension and edema. It may also inhibit hepatic transporters that clear valsartan, modestly raising its exposure.
What this interaction means in plain words
Amlodipine-valsartan and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by ritonavir increases amlodipine levels, and inhibition of OATP1B1 and MRP2 may reduce hepatic clearance of valsartan.
What to do
Monitor blood pressure and edema, and reduce the amlodipine dose if hypotension or edema develops. Check renal function and potassium as appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Ritonavir?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir strongly inhibits CYP3A4 and raises amlodipine levels, increasing the risk of hypotension and edema. It may also inhibit hepatic transporters that clear valsartan, modestly raising its exposure.
How serious is the interaction between Amlodipine-valsartan and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the amlodipine dose if hypotension or edema develops. Check renal function and potassium as appropriate.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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