Drug interactions
Amobarbital + Amoxapine
Severity: Moderate
Amobarbital and Amoxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, so combined use increases drowsiness and psychomotor impairment. Barbiturate enzyme induction may also lower tricyclic-type antidepressant levels, while amoxapine can reduce the seizure threshold.
What this interaction means in plain words
Amobarbital and Amoxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression plus barbiturate induction of hepatic metabolism of the antidepressant.
What to do
Monitor sedation and antidepressant response, adjusting amoxapine dose if efficacy falls. Advise avoiding alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Amoxapine?
MediHelp rates the interaction as moderate. Amobarbital and Amoxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, so combined use increases drowsiness and psychomotor impairment. Barbiturate enzyme induction may also lower tricyclic-type antidepressant levels, while amoxapine can reduce the seizure threshold.
How serious is the interaction between Amobarbital and Amoxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and antidepressant response, adjusting amoxapine dose if efficacy falls. Advise avoiding alcohol and driving.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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