Drug interactions
Amobarbital + Antipyrine
Severity: Minor
Amobarbital and Antipyrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can speed up the clearance of antipyrine, which is used mainly as a probe of hepatic metabolic capacity. The clinical consequence is limited because antipyrine is rarely given therapeutically.
What this interaction means in plain words
Amobarbital and Antipyrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Amobarbital induces hepatic microsomal enzymes, including CYP1A2, increasing antipyrine metabolism.
What to do
No routine action is needed; when antipyrine clearance is used as a liver function test, interpret results in light of recent barbiturate exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Antipyrine?
MediHelp rates the interaction as minor. Amobarbital and Antipyrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and can speed up the clearance of antipyrine, which is used mainly as a probe of hepatic metabolic capacity. The clinical consequence is limited because antipyrine is rarely given therapeutically.
How serious is the interaction between Amobarbital and Antipyrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; when antipyrine clearance is used as a liver function test, interpret results in light of recent barbiturate exposure.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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