Drug interactions
Amobarbital + Budesonide
Severity: Moderate
Amobarbital and Budesonide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is an enzyme inducer and can lower systemic exposure to budesonide, which is a CYP3A4 substrate with high first-pass metabolism. This may reduce the anti-inflammatory efficacy of oral or inhaled budesonide.
What this interaction means in plain words
Amobarbital and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Budesonide belongs to Respiratory.
Why it happens
Barbiturate induction of CYP3A4 increases the metabolism of budesonide.
What to do
Monitor for loss of disease control, such as worsening asthma or Crohn's disease symptoms, and consider a dose increase or a non-inducing sedative alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Budesonide?
MediHelp rates the interaction as moderate. Amobarbital and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital is an enzyme inducer and can lower systemic exposure to budesonide, which is a CYP3A4 substrate with high first-pass metabolism. This may reduce the anti-inflammatory efficacy of oral or inhaled budesonide.
How serious is the interaction between Amobarbital and Budesonide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of disease control, such as worsening asthma or Crohn's disease symptoms, and consider a dose increase or a non-inducing sedative alternative.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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