Drug interactions
Amobarbital + Buprenorphine buccal
Severity: Major
Amobarbital and Buprenorphine buccal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a barbiturate with buprenorphine increases the risk of profound sedation, respiratory depression, coma and death. The risk is notable even though buprenorphine is a partial agonist.
What this interaction means in plain words
Amobarbital and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism and GABA-A potentiation.
What to do
Avoid concurrent use where possible, or use the lowest effective doses for the shortest duration with close monitoring of sedation and respiration. Counsel patients and caregivers about warning signs of overdose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Buprenorphine buccal?
MediHelp rates the interaction as major. Amobarbital and Buprenorphine buccal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a barbiturate with buprenorphine increases the risk of profound sedation, respiratory depression, coma and death. The risk is notable even though buprenorphine is a partial agonist.
How serious is the interaction between Amobarbital and Buprenorphine buccal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, or use the lowest effective doses for the shortest duration with close monitoring of sedation and respiration. Counsel patients and caregivers about warning signs of overdose.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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