Drug interactions
Amobarbital + Buprenorphine subdermal implant
Severity: Major
Amobarbital and Buprenorphine subdermal implant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates combined with buprenorphine cause additive CNS and respiratory depression, with risk of profound sedation, coma or death. The implant cannot be quickly adjusted, so effects may be prolonged.
What this interaction means in plain words
Amobarbital and Buprenorphine subdermal implant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS and respiratory depression; amobarbital may also induce CYP3A4 metabolism of buprenorphine.
What to do
Reserve for patients without alternatives and monitor for sedation and respiratory depression. Consider removing the implant or stopping amobarbital if excessive sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Buprenorphine subdermal implant?
MediHelp rates the interaction as major. Amobarbital and Buprenorphine subdermal implant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates combined with buprenorphine cause additive CNS and respiratory depression, with risk of profound sedation, coma or death. The implant cannot be quickly adjusted, so effects may be prolonged.
How serious is the interaction between Amobarbital and Buprenorphine subdermal implant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for patients without alternatives and monitor for sedation and respiratory depression. Consider removing the implant or stopping amobarbital if excessive sedation occurs.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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