Drug interactions
Amobarbital + Clemastine
Severity: Moderate
Amobarbital and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a barbiturate with a sedating antihistamine increases drowsiness and psychomotor impairment. The effect is more pronounced with alcohol and in older adults.
What this interaction means in plain words
Amobarbital and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Clemastine belongs to Respiratory.
Why it happens
Additive CNS depression through GABAergic enhancement and H1 receptor blockade.
What to do
Warn patients about impaired driving and alcohol, and consider a non-sedating antihistamine. Reduce doses if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Amobarbital with Clemastine?
MediHelp rates the interaction as moderate. Amobarbital and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a barbiturate with a sedating antihistamine increases drowsiness and psychomotor impairment. The effect is more pronounced with alcohol and in older adults.
How serious is the interaction between Amobarbital and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about impaired driving and alcohol, and consider a non-sedating antihistamine. Reduce doses if drowsiness is excessive.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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