Drug interactions
Amobarbital + Difenoxin
Severity: Moderate
Amobarbital and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal metabolite of diphenoxylate, and with a barbiturate it can produce additive sedation. Respiratory depression is possible, particularly with excessive doses or in children.
What this interaction means in plain words
Amobarbital and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from barbiturate GABA-A potentiation and opioid receptor activity.
What to do
Use the lowest effective doses and monitor for excessive drowsiness and slowed breathing. Counsel patients to avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Difenoxin
Frequently asked questions
Can I take Amobarbital with Difenoxin?
MediHelp rates the interaction as moderate. Amobarbital and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal metabolite of diphenoxylate, and with a barbiturate it can produce additive sedation. Respiratory depression is possible, particularly with excessive doses or in children.
How serious is the interaction between Amobarbital and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive drowsiness and slowed breathing. Counsel patients to avoid driving.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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