Drug interactions
Amobarbital + Erythromycin ethylsuccinate
Severity: Moderate
Amobarbital and Erythromycin ethylsuccinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can induce CYP3A4 and lower erythromycin concentrations, potentially reducing antibacterial effect. The effect is typically modest and clinically manageable.
What this interaction means in plain words
Amobarbital and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by amobarbital increases erythromycin metabolism.
What to do
Monitor for clinical response to the antibiotic and consider an alternative antibiotic if treatment is failing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Erythromycin ethylsuccinate?
MediHelp rates the interaction as moderate. Amobarbital and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can induce CYP3A4 and lower erythromycin concentrations, potentially reducing antibacterial effect. The effect is typically modest and clinically manageable.
How serious is the interaction between Amobarbital and Erythromycin ethylsuccinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clinical response to the antibiotic and consider an alternative antibiotic if treatment is failing.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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