Drug interactions
Amobarbital + Escitalopram
Severity: Moderate
Amobarbital and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may lower escitalopram concentrations by inducing its metabolizing enzymes, possibly reducing antidepressant effect. Additive CNS depression and sedation may also occur.
What this interaction means in plain words
Amobarbital and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Escitalopram belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 and CYP2C19 increases escitalopram clearance, plus additive CNS depression.
What to do
Monitor for loss of antidepressant response and for excess sedation. Increase the escitalopram dose if needed within the labeled range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Amobarbital with Escitalopram?
MediHelp rates the interaction as moderate. Amobarbital and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may lower escitalopram concentrations by inducing its metabolizing enzymes, possibly reducing antidepressant effect. Additive CNS depression and sedation may also occur.
How serious is the interaction between Amobarbital and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response and for excess sedation. Increase the escitalopram dose if needed within the labeled range.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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