Drug interactions
Amobarbital + Ethotoin
Severity: Moderate
Amobarbital and Ethotoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates may alter the metabolism of hydantoin anticonvulsants, and the net effect on ethotoin levels is not predictable. Both drugs are sedating, so the combination can also add to CNS depression.
What this interaction means in plain words
Amobarbital and Ethotoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Hepatic enzyme induction by the barbiturate may increase ethotoin metabolism, plus additive CNS depression.
What to do
Monitor seizure control and sedation, and check anticonvulsant levels or clinical response when starting or stopping amobarbital.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Ethotoin?
MediHelp rates the interaction as moderate. Amobarbital and Ethotoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates may alter the metabolism of hydantoin anticonvulsants, and the net effect on ethotoin levels is not predictable. Both drugs are sedating, so the combination can also add to CNS depression.
How serious is the interaction between Amobarbital and Ethotoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation, and check anticonvulsant levels or clinical response when starting or stopping amobarbital.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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