Drug interactions
Amobarbital + Etoposide
Severity: Moderate
Amobarbital and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce etoposide exposure by inducing CYP3A4, potentially lowering antineoplastic efficacy. Enzyme inducers have been associated with higher etoposide clearance.
What this interaction means in plain words
Amobarbital and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Etoposide belongs to Oncology.
Why it happens
Barbiturate induction of CYP3A4 increases etoposide metabolic clearance.
What to do
Prefer a non-inducing anticonvulsant or sedative where possible and monitor response and myelosuppression, adjusting etoposide dosing as clinically needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Amobarbital with Etoposide?
MediHelp rates the interaction as moderate. Amobarbital and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may reduce etoposide exposure by inducing CYP3A4, potentially lowering antineoplastic efficacy. Enzyme inducers have been associated with higher etoposide clearance.
How serious is the interaction between Amobarbital and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing anticonvulsant or sedative where possible and monitor response and myelosuppression, adjusting etoposide dosing as clinically needed.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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