Drug interactions
Amobarbital + Exemestane
Severity: Moderate
Amobarbital and Exemestane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may lower exemestane concentrations through CYP3A4 induction, potentially reducing efficacy in breast cancer treatment. Labeling advises a higher exemestane dose with potent CYP3A4 inducers.
What this interaction means in plain words
Amobarbital and Exemestane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Exemestane belongs to Oncology.
Why it happens
Barbiturate induction of CYP3A4 increases exemestane metabolism.
What to do
Consider increasing exemestane to 50 mg daily after a meal while the inducer is used, and revert when it is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Exemestane
Frequently asked questions
Can I take Amobarbital with Exemestane?
MediHelp rates the interaction as moderate. Amobarbital and Exemestane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may lower exemestane concentrations through CYP3A4 induction, potentially reducing efficacy in breast cancer treatment. Labeling advises a higher exemestane dose with potent CYP3A4 inducers.
How serious is the interaction between Amobarbital and Exemestane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider increasing exemestane to 50 mg daily after a meal while the inducer is used, and revert when it is stopped.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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