Drug interactions
Amobarbital + Fentanyl iontophoretic transdermal system
Severity: Major
Amobarbital and Fentanyl iontophoretic transdermal system: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and opioids together cause additive CNS and respiratory depression, with risk of profound sedation, coma and death. Enzyme induction by amobarbital may also reduce fentanyl effect.
What this interaction means in plain words
Amobarbital and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression plus CYP3A4 induction by amobarbital.
What to do
Reserve for patients without alternatives and monitor sedation and respiratory rate closely. Reassess analgesia if amobarbital is started or stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Fentanyl iontophoretic transdermal system?
MediHelp rates the interaction as major. Amobarbital and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and opioids together cause additive CNS and respiratory depression, with risk of profound sedation, coma and death. Enzyme induction by amobarbital may also reduce fentanyl effect.
How serious is the interaction between Amobarbital and Fentanyl iontophoretic transdermal system?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for patients without alternatives and monitor sedation and respiratory rate closely. Reassess analgesia if amobarbital is started or stopped.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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